Samrudhdi Health
Equipments Pvt. Ltd.

Synthra RNplus is a flexible and completely automated radio synthesis system for routine production of wide variety of [18F]fluorine labeled compounds by nucleophilic substitution, with automated sequences for compounds like [18F]F-DOPA, [18F]FDG, [18F]FLT, [18F]FET, [18F]FHBG, [18F]FDDNP, [18F]MISO, [18F]FAZA, [18F]FES and [18F] Fluorocholine. For any other [18F]labeled customer compounds an automated sequence will be generated. The synthesis unit includes all components needed for preparation, labeling, purification and formulation of [18F]fluorine labeled compounds. Automating the synthesis is simple, with the easy-to-use configuration software Synthra View, the Synthra RNplus module offers both, fully automatic and manual modes of operation.

The radio synthesis system has a dedicated sub system for the recovery and collection of [18O]H2O for the purification of the cyclotron produced [18F]fluoride. The target activity is measured with a separated detector.

There are two synthesis reaction vessels and one column oven for a solid support reaction zone, allowing multiple step (homogenous and heterogeneous) synthesis reactions. The reaction vessels include PID controlled heaters for a temperature range between -50 °C and 250 °C. The optimized heating and cooling from 20 °C to 100 °C takes only 1 minute. A collection pipe for the exhausted cooling gas is provided. Each reaction vessel is equipped with a pressure transducer, a temperature sensor and a radioactivity detector.