Synthra RNplus is a flexible and completely automated radio synthesis system for routine production of wide variety of [18F]fluorine labeled compounds by nucleophilic substitution, with automated sequences for compounds like [18F]F-DOPA, [18F]FDG, [18F]FLT, [18F]FET, [18F]FHBG, [18F]FDDNP, [18F]MISO, [18F]FAZA, [18F]FES and [18F] Fluorocholine. For any other [18F]labeled customer compounds an automated sequence will be generated. The synthesis unit includes all components needed for preparation, labeling, purification and formulation of [18F]fluorine labeled compounds. Automating the synthesis is simple, with the easy-to-use configuration software Synthra View, the Synthra RNplus module offers both, fully automatic and manual modes of operation.

The radio synthesis system has a dedicated sub system for the recovery and collection of [18O]H2O for the purification of the cyclotron produced [18F]fluoride. The target activity is measured with a separated detector.

There are two synthesis reaction vessels and one column oven for a solid support reaction zone, allowing multiple step (homogenous and heterogeneous) synthesis reactions. The reaction vessels include PID controlled heaters for a temperature range between -50 °C and 250 °C. The optimized heating and cooling from 20 °C to 100 °C takes only 1 minute. A collection pipe for the exhausted cooling gas is provided. Each reaction vessel is equipped with a pressure transducer, a temperature sensor and a radioactivity detector.

Flexible and completely automated radio synthesis system  Production of wide variety of Fluorine-18 labelled compounds by nucleophilic substitution

  • [18F]F-DOPA
  • [18F]FDG
  • [18F]FLT
  • [18F]FHBG
  • [18F]FDDNP
  • [18F]MISO
  • [18F]FAZA
  • [18F]Fluorocholin

SYNTHRA RN plus module offers both fully automatic and manual modes of operation.

Technical Description

  • Built-in filter integrity test for final filtration
  • Built-in preparative Radio/HPLC system for product collection
  • Two glassy carbon reaction vessels for homogenous reactions
  • Column oven for solid support reactions
  • Two pressure transducers to monitor reaction vessel pressure
  • Chemically inert valves with low dead volume
  • Chemically inert vacuum pump
  • 15 glass vials for reagents
  • O-18 water recovery capability
  • Chemical inert dispenser
  • Automatic, pneumatic injection valve

 All wetted components are chemical inert

Dimensions and Weight Size (WxDxH) 53 x 50 x 50 cm

Weight Approx. 45 kg                                            

Minimum Hot cell size:- 65 x 50 x 50 cm