[C11] CARBON SYNTHESIZER MELPLUS
A flexible and completely automated synthesis system for routine production of wide variety of Carbon-11 labeled compounds based on the generation of gas-phase C-11 Methyl Iodide or optional C-11 Methyl Triflate synthesis. Automating the synthesis is simple, with easy-to-use configuration software the Synthra MeIplus module offers both fully automatic and manual modes of operation.
Using in-target produced Carbon dioxide, high specific activity preparations are produced ranging from 10 Ci/μmol to 24 Ci/μmol when high purity target gas is used for [11C]-CO2 production.
- Built-in filter integrity test for final filtration
- Built-in preparative Radio/HPLC system for product collection
- Reaction vessel with integrated cooling to reduce reaction time
- Column oven for solid support CH3I reactions
- Chemically inert valves with low dead volume
- Chemically inert vacuum pump
- 7 glass vials for reagents
- Three electronic flow controllers
- One leak detector
- Chemical inert dispenser
- Automatic, pneumatic injection valve
- All wetted components are chemical inert
[11C] compounds [11C]
Radiotracer Target Application
Raclopride D2 dopamine receptors Neuropsychiatric disorders
DASP D2 dopamine receptors Neuropsychiatric disorders
Flumazenil Benzodiazepine receptor Neurodegenerative diseases
Methionine Amino acid transporter Brain, head and neck, lung and
Breast cancer, lymphomas
Choline Choline kinase Brain tumours, prostate, lung and
esophageal cancer
Thymidine Thymidine kinase-1 Tumour proliferation
Palmitate Myocardial tissue fatty
acid metabolism Heart diseases
Specifications Yields
>50% for [11C]-CH3I in less than 8 min
Time for sequential synthesis <10 min
Number of consecutive [11C]-CH3I synthesis < 15